Defining a responder in treatment trials for chronic idiopathic constipation
نویسندگان
چکیده
منابع مشابه
Outcome of behavioural treatment for idiopathic chronic constipation.
BACKGROUND/AIM Behavioural therapy is effective in patients with chronic intractable constipation despite standard treatment, but long-term results in unselected patients are unclear. This study investigates the effects of behavioural therapy on symptoms, subjective well-being, and the physical and mental quality of life. METHODS Patients who had failed standard care for idiopathic chronic co...
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BACKGROUND While chronic constipation (CC) clinical trials have focused primarily on bowel symptoms (symptoms directly related to bowel movements), abdominal symptoms are also prevalent among patients. The United States Food and Drug Administration's (FDA's) guidance on the use of patient-reported outcome measures to support product approvals or labeling claims recommends that endpoints be deve...
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Chronic idiopathic constipation (CC) and irritable bowel syndrome with predominant constipation (IBS-C) are the 2 most common conditions among functional gastrointestinal disorders. Despite current multiple therapeutic options, treatment remains challenging and dissatisfactory to many patients. Linaclotide is a novel therapeutic agent, which is a guanylate cyclase receptor agonist that stimulat...
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Chronic constipation is highly prevalent, reduces patients' quality of life, and imposes a significant health care burden on society. Lifestyle modifications and over-the-counter agents improve symptoms of constipation in some patients, however many patients have persistent symptoms and require the use of prescription medications. Three prescription medications are currently Food and Drug Admin...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2010
ISSN: 0269-2813
DOI: 10.1111/j.1365-2036.2010.04504.x